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Eamonn Farrell via RollingNews.ie

Pfizer starts large trial for anti-Covid pill

Several companies are working on so-called oral antivirals.

PFIZER TODAY SAID it had begun a middle-to-late stage clinical trial of a pill to stave off Covid in people who are exposed to infection.

Several companies are working on so-called oral antivirals, which would mimic what the drug Tamiflu does for influenza and prevent the disease from progressing to severe.

“We believe that tackling the virus will require effective treatments for people who contract, or have been exposed to, the virus, complementing the impact that vaccines have had,” said Mikael Dolsten, the company’s chief scientific officer.

Pfizer started developing its drug, called PF-07321332, in March 2020 and is testing it in combination with ritonavir, a repurposed HIV medicine.

The clinical trial will enroll 2,660 adults who will take part at the first signs of Covid infection or at first awareness of exposure.

They will be randomly assigned to receive either a combination of PF-07321332 and ritonavir, or a placebo twice a day for five or ten days.

The objective is to assess the safety and efficacy of the drugs being studied at preventing SARS-CoV-2 infection and symptomatic disease by day 14.

Other companies are also testing existing oral antivirals against Covid — but Pfizer’s is the first specifically designed against the coronavirus.

It is known as a “protease inhibitor” and has been shown in lab testing to jam up the virus’ replication machinery.

If it works in real life, it will likely only be effective at the early stages of infection.

By the time Covid progresses to severe disease, the virus has largely stopped replicating and patients suffer from an over-active immune response.

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    Mute Ger
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    Sep 27th 2021, 4:08 PM

    This will be a game changer once its ready and effective. Covid will be with us for a long time and tablets are a lot easier to distribute than vaccines and boosters, especially in poor countries. They will save a lot of lives.

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    Mute Luke
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    Sep 29th 2021, 7:49 PM

    @Ger: maybe it’ll be dished out like the iodine tablet years ago? Wonder how many still have theirs!

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    Mute simon Barr
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    Sep 27th 2021, 4:05 PM

    Is there something wrong with Vitamin C, D or Zinc?

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    Mute Niamh Brady
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    Sep 27th 2021, 4:09 PM

    @simon Barr: Yes, it doesn’t stop Covid progressing if you catch it, would have thought that was kind of obvious.

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    Mute Ger
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    Sep 27th 2021, 4:09 PM

    @simon Barr: ask your GP. Zero affect against Covid19. You’ll have expensive pee though.

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    Mute Dan Broderick
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    Sep 27th 2021, 4:19 PM

    @Ger: cool quote from the big bang theory….vitamin d deficiency has been known to be the single biggest predictor of a poor covid outcome, vitamin c in very high doses can drastically reduce the duration of the virus.
    30g of vitamin c per day and you’ll speed up recovery, from personal experience.

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    Mute Simon Connolly
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    Sep 27th 2021, 4:33 PM

    @Dan Broderick: 30g of Vitamin C??!! How many tubes of tablets is that?? Nevermind the cost!!

    49
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    Mute Dave Lanigan
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    Sep 27th 2021, 4:40 PM

    @simon Barr: wow why didnt anyone think of that ? You should get onto the most educated medical experts on the planet working on this and let them know!

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    Mute Ger
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    Sep 27th 2021, 4:53 PM

    @Dan Broderick: so was your “personal experience” reviewed by a doctor or a virologist who concluded that the supplements “sped up your recovery” or did you just get over it relatively quickly and decide on your own that it must have been the Vit C?

    74
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    Mute Clubhouse Barman.
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    Sep 27th 2021, 5:03 PM

    Prof Luke O’Neill recommends extra Vitamin D. He says if you have a well balanced diet, taking vitamin c is probably a waste of time.

    21
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    Mute Francis Devenney
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    Sep 27th 2021, 5:24 PM

    @simon Barr: You need about 40mg of vitC a day which you get from s half decent diet, taking larger doses is pointless as your body can;t store it. As for vitD you need about 100 micrograms, sunlight and a decent diet will give you all that. Zinc unless you’re a vegan you will also get enough from your diet.Also you need to be careful if you have a healthy diet and take a zinc supplement you can run into all sorts of health issues. Couple that with the fact that there is no evidence that any of those help with covid and yeah! you just end up with expensive pee.

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    Mute Kevin Kilcoyne
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    Sep 27th 2021, 5:41 PM

    @simon Barr: Pfizer can’t make money from them would be the biggest barrier to their widespread use. Also, while Vit D has been shown to improve outcomes from the disease, the effect is likely an order of magnitude smaller than clinically developed medications. Very little discussion on Obesity either, which is the biggest factor in predicting the impacts of Covid on a population level (alongside age).

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    Mute Francis Devenney
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    Sep 27th 2021, 5:55 PM

    @Kevin Kilcoyne: Both Centrum and Alacer are owned by Pfizer, so yes, they do make money from them. I think it’s about a dozen or so corporations that own nearly all the health supplement brands out there,

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    Mute Conor Farrell
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    Sep 27th 2021, 5:58 PM

    @Dan Broderick: 30 grams of vitamin C?? The safe upper limit is about 2 grams! Just as well I don’t take medical advice from the comments section of TheJournal, and if I were you I’d stop taking medical advice from wherever it is you’re getting it from.

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    Mute Anarch Eco
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    Sep 27th 2021, 6:10 PM

    @simon Barr: quick get the elderberries before the birds have them ate. (Loads of Vit C)

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    Mute Dan Broderick
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    Sep 27th 2021, 6:42 PM

    @Conor Farrell: there is no upper limit for vitamin c, >10g can result in a laxative effect if taken over a short space of time, but your body gives enough feedback before that happens. If your body is fighting an infection, it will utilise far more vitamin c than usual….mega doses of vitamin c have been used my many people for a long time now.
    Who knows, maybe it’s just a placebo effect but I’ve probably researched it more than anybody else on this thread.

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    Mute NotMyIreland
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    Sep 27th 2021, 7:14 PM

    @Dan Broderick: As you have researched it more than anyone else you would know that our bodies are configured to keep vitamin C levels within a particular range… As you take in more vitamin C, the amount you absorb from each dose goes down. Then once it is absorbed and goes in the blood, there are proteins on the cell that bring vitamin C into the tissue, and those proteins can’t work any faster. Then the excess vitamin C is excreted through the kidneys in urine. So mega doses only bring the levels in the tissues to the same as an RDA dose. I think it is a sort of placebo. Granted I still take mega doses when sick as it will do no harm, but I dont treat it as a cure or something that prevents you getting sick.
    Vit D is a different story and I definitely dont get sick as often or for as long when regularly taking it.

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    Mute change is needed
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    Sep 27th 2021, 7:41 PM

    @Dan Broderick: completely agree

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    Mute Anto Gunning
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    Sep 27th 2021, 8:44 PM

    @Ger: In the latest study, published in July 2021, researchers enrolled 191 COVID patients and 203 healthy individuals and found that 84.4% of the patients were deficient in vitamin D

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    Mute William Tallon
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    Sep 27th 2021, 4:39 PM

    No doubt it’ll be a bitter pill for some resolute ‘anti-vaxxers’ to swallow! A lot easier for Bill Gates to microchip people through a pill obviously. The perfect delivery system. Now if only they could develop a pill to combat paranoia…

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    Mute Crypto S. Crazii
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    Sep 27th 2021, 5:25 PM

    @William Tallon: Curious as to why you think somebody with with an apprehension towards mRNA technology would also be apprehensive towards a protease inhibitor?

    Could it possibly be that you couldn’t resist the temptation to squeeze in “a bitter pill” in order to try to be funny?

    Could it be that you have a very limited understanding between differences in the two methods of therapeutic delivery?

    Or, could it be that you’re lazy use of the propaganda driven “anti-vaxxers” language is just easier to use so as to vilify a group of people that has differing opinions/concerns to yours?

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    Mute Bert Carolan
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    Sep 27th 2021, 5:30 PM

    @William Tallon: Some of these antivaccers are dangerous, see the case of the Donegal man pursuaded to leave hospital and died a few days later. If you believe your own bullshut and want to do crazy stuff yourself that’s fine, influencing others is a different story.

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    Mute Bert Carolan
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    Sep 27th 2021, 5:32 PM

    @Crypto S. Crazii: What’s your opinion on the case in Donegal then?

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    Mute Crypto S. Crazii
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    Sep 27th 2021, 5:35 PM

    @Bert Carolan: I think you’ll find that foolishness is not exclusive to either group. Humans makes bad decisions irrespective of vaccination status. Are you saying that all vaccinated people = pillars of society?

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    Mute Crypto S. Crazii
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    Sep 27th 2021, 5:37 PM

    @Bert Carolan: I don’t have an opinion on it particularly. Foolish people will make poor choices regardless of whether they’re vaccinated or not.

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    Mute William Tallon
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    Sep 27th 2021, 5:48 PM

    @Crypto S. Crazii: Wow! That’s some curiosity you have there to be sure. I was beginning to take you seriously until the latter half of your comment. I seem to have touched a raw nerve resulting in a somewhat paranoid and defensive conclusion to it. Of course I couldn’t resist the temptation to squeeze in the ‘bitter pill’ reference. Sometimes humour is the only weapon left when reason and logic fails. ‘Anti-vaxxers’ albeit lazy shorthand is an apt description for people holding certain attitudes and views specifically in relation to Covid vaccines. Speaking of humour, if they ever develop a pill for that maybe you should consider taking it…

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    Mute Drunk in Dublin
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    Sep 27th 2021, 6:13 PM

    @Crypto S. Crazii: lol, thinking that using the term “anti-vaxxers” is due to “propaganda”. Sweetheart, there have been anti-vaxxers for centuries. Grow up.

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    Mute Crypto S. Crazii
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    Sep 27th 2021, 6:22 PM

    @William Tallon: It’s absolutely not an apt description. You’ll likely find that most people who are ‘Anti-vax’ as you describe them are in fact not against vaccination at all! Just this one.. So to label people as such, promotes an agenda because its simply not true.
    I wouldn’t go as far as saying, touched a raw nerve, but I am disappointed by the deliberate blanket ridiculing that seems to have become normal across the board.
    In addition, if what you posted passes as humour for you, barrel scraping is obviously something that comes natural for you.

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    Mute Crypto S. Crazii
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    Sep 27th 2021, 6:27 PM

    @Drunk in Dublin: Centuries? Give me a break!
    Anti-vaxxer promotes the idea of somebody that is completely against ALL vaccines. This is not the case here for 99.9% of people that have concerns regarding THIS vaccine. But don’t let that get in the way of you painting them as crazy people.

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    Mute Terry Cahill
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    Sep 27th 2021, 6:39 PM

    @Bert Carolan: whoever convinced that man to leave the hospital only to be readmitted and die needs to be held to account … I’m being cautious with my words .

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    Mute William Tallon
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    Sep 27th 2021, 6:44 PM

    @Crypto S. Crazii: Judging by your response I definitely would go so far as saying I’ve touched a raw nerve! It’s almost adolescent in its defensiveness. What people consider humour is obviously down to individual taste and so one person’s barrel scrapings can be another’s source of amusement. In your case though you seem to be a particularly humourless person, which is obviously something that comes naturally to you…

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    Mute Crypto S. Crazii
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    Sep 27th 2021, 6:52 PM

    @William Tallon: Can you explain to me your idea of adolescent defensiveness? And remember in your answer that you’re the one defending your jibe as “source of amusement”. Your attempt at being clever is weak..

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    Mute William Tallon
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    Sep 27th 2021, 6:53 PM

    @Crypto S. Crazii: QED…

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    Mute Bert Carolan
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    Sep 27th 2021, 7:02 PM

    @Terry Cahill: I would agree but I can’t see it happening. There is a lot involved here, right to receive information, right to make your own decisions, general rights of the individual.
    Very few people would argue that individuals and groups should not be given access to a public platform to desiminate views encouraging violence towards minority groups. Yet there are groups who advocate views that can lead to people’s I’ll health and in this case death. Should these groups have a public platform ie social media?
    What I can say for certain is that this case was a genuine tragedy.

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    Mute Paul Whitehead
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    Sep 28th 2021, 7:30 AM

    @Crypto S. Crazii: This vaccine has saved millions of lives. While the vaccinated may not always be pillars of society, Anti-vaxxers are dangerous irresponsible people who care little for the health of others and society in general. They tend to be ‘please notice me- Im not a sheeple, I’m different’ types who get their news from FB. I haven’t heard of anyone i know dying from a covid vaccine. No bodies on the street as predicted. Yet 90% of people I know are vaccinated.

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    Mute Crypto S. Crazii
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    Sep 28th 2021, 8:40 AM

    @Paul Whitehead: You’re making a lot of assumptions based on what you see and hear from others. The Times reported on Sunday https://www.thetimes.co.uk/article/e9779472-1e4a-11ec-9699-f7cb5224a0e1?shareToken=700d7b4b95a1c810554a6efe2d6b1fee
    that 186 people in Beaumont hospital (including nurses & clinicians – one of which I know personally & speak to regularly) have refused the vaccine.
    Do these people sound like the dangerous irresponsible people who care little for the heath of others for which you describe with such vigour and disgust? Do these fit the FB demographic you call out?
    You see, it’s easy to throw out sweeping assertions that fit your bias and serve to make monsters of otherwise rational people. ‘Anti-vaxxer’ should not be used for people who have made a ‘personal choice’.

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    Mute David Van-Standen
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    Sep 27th 2021, 7:02 PM

    People have become so polarised on this subject, that objectivity seems impossible, they are divided into what they see as, on the one hand science is good, don’t question anything, verses anyone questioning anything is an antivaxxer nutcase on the other.

    The funny thing is, that before covid19, questioning everything, was science.

    To look at this objectively you would need to suspend those polarised positions and look at the most important questions..

    •Who will benefit financially from this covid pill development and to what extent?

    •Does repurposing existing antiviral research and treatments for hiv/aids etc, into a covid anti viral pill, equal innovative altruistic science, or shrewd corporate business practice?

    •Does this product development result in a repeat business model?

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    Mute Crypto S. Crazii
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    Sep 27th 2021, 7:18 PM

    @David Van-Standen: Very well put and wholeheartedly agree!

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    Mute Phil Quinn
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    Sep 28th 2021, 8:41 AM

    @David Van-Standen: Questioning everything was science if your a scientist….pre & post covid.
    Not that questioning everything is wrong….vaccine came around v quickly when scientists themselves said it would take minimum 2 years…but your questions above are more anticapitalism than science.

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    Mute Rob Gale
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    Sep 27th 2021, 6:50 PM

    PF-07321332 .. catchy name. Can hear the ad jingles already.

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    Mute Murph11
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    Sep 27th 2021, 8:17 PM

    Last time I took a Pfizer tablet it got stuck in my throat. I had a stiff neck for a few hours. Yeah yeah I’m getting my coat

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